Preheat oven to 375°F (190°C) and lightly spray a baking dish with nonstick cooking spray.

In a large bowl, combine ground turkey, breadcrumbs, onion, garlic, egg, and ketchup. Mix using your hands until just combined.

Season generously with salt and pepper. Shape the mixture into a loaf and place it in the prepared baking dish.

In a separate bowl, mix brown sugar and Worcestershire sauce. Spread over the top of the meatloaf.

Bake for approximately 60 minutes or until the internal temperature reaches 165°F (74°C). Allow to rest for 10 minutes before slicing.